Gene_ID	Gene_name	No of mutations needed	Codon_pos	Ref_nuc	Ref_codon	Res_codon	Notes if any
penA	penA	1	501	GCG	A	V,T,P
penA	penA	1	551	CCG	P	S,L	note: only statistically associated with enhanced resistance
penA	penA	1	542	GGC	G	S	note: only statistically associated with enhanced resistance
penA	penA	1	346	---	ins	D	note: only statistically associated with enhanced resistance
mtrR	mtrR	1	45	GAC	D	G	
pilQ	pilQ	1	666	GAA	E	K	note: only effective in the presents of the mtrR and penB (porB mutation) resistance determinants
rpsJ	rpsJ	1	57	GTG	V	M,L,Q	
rpsE	rpsE	1	27	GTT	V	del	
rpsE	rpsE	1	28	AAA	K	E	note: Mutation seen together with V27 deletion
rpsE	rpsE	1	24	ACC	T	P	note: low-level resistance
gyrA	gyrA	1	91	TCC	S	F	note: Mutation often seen together with D95N/G mutation
gyrA	gyrA	1	95	GAC	D	N,G	note: Mutation seen together with D95N/G mutation
parC	parC	1	91	GAG	E	G,Q,K	note: High-level resistance when additional to gyrA S91P and gyrA D95N/G mutation
parC	parC	1	88	TCC	S	P	note: High-level resistance when additional to gyrA S91P and gyrA D95N/G mutation
porB	porB	1	120	GGC	G	D	note: Resistance seen when additional to porB A121D mutation, alone only partial resistance
porB	porB	1	121	GCC	A	D	note: Resistance seen when additional to porB G120D mutation, alone only partial resistance
porB	porB	1	120	GGC	G	R	note: Resistance seen when additional to porB A121H mutation
porB	porB	1	121	GCC	A	H	note: Resistance seen when additional to porB G120R mutation
porB	porB	1	120	GGC	G	P	note: Resistance seen when additional to porB A121P mutation
porB	porB	1	121	GCC	A	P	note: Resistance seen when additional to porB G120P mutation
porB	porB	1	120	GGC	G	K	
ponA	ponA	1	421	CTG	L	P	note: Mutation mediates transformation of intermediate-level penicillin-resistant transformants to high-level penicillin resistance
16S_rRNA	16S_rRNA	1	1192	C	C	T	
23S_rRNA	23S_rRNA	1	2604	C	C	T	note: C2611T mutation (Escherichia coli numbering)
23S_rRNA	23S_rRNA	1	2603	C	C	T	note: C2611T mutation (Escherichia coli numbering)
23S_rRNA	23S_rRNA	1	2603	C	C	T	note: C2611T mutation (Escherichia coli numbering)
23S_rRNA	23S_rRNA	1	2610	C	C	T	note: C2611T mutation (Escherichia coli numbering)
23S_rRNA	23S_rRNA	1	2051	A	A	G	
23S_rRNA	23S_rRNA	1	2050	A	A	G	
23S_rRNA	23S_rRNA	1	2050	A	A	G	
23S_rRNA	23S_rRNA	1	2054	A	A	G	
mtrR_locus	mtr_locus	1	134	C	C	T	note: mutation generates a consensus -10 hexamer sequence (TATAAC -> TATAAT) a novel promoter (mtr120)	21933917
mtrR_locus	mtrR_promotor	1	56	T	T	del	note: often denoted as nucleotide [A] deletion in 13-bp inverted repeat	24982323
macAB_pro	macAB_promotor	1	178	G	G	T	
